The Potential Role of Stress in Insulin Resistance

Abstract

Insulin resistance is a common syndrome in both developed and developing countries. It is a risk factor for type 2 diabetes mellitus, which is the most common end stage of metabolic syndrome in the Philippines. Previously, research into type 2 diabetes focused on pancreatic beta cell failure and insulin resistance, as well as approaches to rectify these dysfunctions. However, there has been a surge of interest in recent years in the role that stress in peripheral tissues plays in the development of insulin resistance. The goal of this review is to concentrate on the mechanism of oxidative species formation and its direct relationship to insulin resistance, to address the role of stress in insulin stimulation through the disruption of different molecular pathways in target tissues. To discuss the role of stress in insulin Brain and Body Arousal, the cited condition that can be addressed through pharmacologically and therapeutically, and to investigate the potential consequences of this phenomenon.