Estimation of Telomeric Length as Critical Concern Towards Cellular Senescence and Age-Related Diseases

Abstract

Telomeres are essential genomic regions in many organisms including eukaryotes. Irregular shortening of telomeres can be life-threatening when it leads to its dysfunction and early ageing would led the particular cell to reach pre-mature cell death. Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. The shortest telomeres that trigger DNA damage responses leading to replicative senescence in mammals. Therefore, determination of telomeric length is very important in preventing body dysfunction to take place.